Two cases of fatal PML have been reported in the US in association with the use of efalizumab for the treatment of plaque psoriasis. Both cases occurred in patients aged 70 years or older, who received efalizumab continuously for approximately 4 years. 

Epidemiological studies have associated androgenetic alopecia (AGA) to severe young-age coronary artery disease and hypertension, and linked it to insulin resistance. We carried out a case-control study in age and weight-matched young males to study the link between AGA and insulin resistance using the HOMA-IR index or metabolic syndrome clinical manifestations.  

Itch significantly impairs the quality of life of patients with atopic dermatitis. However, only a few previous studies have examined the specific characteristics of itch in atopic dermatitis. 

 In spite of current therapies, the overall health status of patients with SLE is poor. High-dose cyclophosphamide (50 mg/kg for 4 days) with or without stem-cell rescue has been introduced as a new therapy for severe SLE, including renal and central nervous system (CNS)-SLE.

Alopecia areata (AA) appears in several clinical forms, all having different clinical courses and different prognoses. Acute diffuse and total alopecia (ADTA) has been reported to have a short clinical course ranging from acute hair loss to total baldness, followed by rapid recovery.